EFFICACY AND SAFETY OF RADOTINIB IN CHRONIC PHASE CHRONIC MYELOID LEUKEMIA PATIENTS WITH RESISTANCE OR INTOLERANCE TO BCR-ABL1 TYROSINE KINASE INHIBITORS

Radotinib (IY5511HCL), a novel and selective BCR-ABL1 tyrosine kinase inhibitor, has shown pre-clinical and phase I activity and safety in chronic myeloid leukemia.This phase II study investigated the efficacy and safety of radotinib in Philadelphia chromosome-positive chronic phase-chronic myeloid leukemia patients with resistance and/or intoleran

Human activity combined with the dynamics of severe climate conditions are accepted the main drivers Acne of wildfire events in the Mediterranean region.This fact is urging for further comprehensive research focusing on the wildland-urban interface (WUI) at metropolitan scale, at which the tension between the cause and effect of wildfire is the hig

This study presents a simple and Cutting Board Brushes innovative design to join a 2 mm thick steel sheet to a 5 mm thick aluminium sheet in a butt configuration.Thickness differences were addressed using support plates, while an aluminium run-on plate was employed to prevent the FSW tool from plunging into the steel.The process produced a unique S

Many governments and private projects are done by contractor.They get projects in a competitive bid auction environment.A contractor in order to overcome to other competitors in a bid auction, opportunely cuts down biding price(bids project at or below minimum profit Cutting Board Brushes level) and wins the contract, and hopes to recover the loss